Selinger says dikes in the area are higher and drier than the last flood in 2011, but time will tell whether all the defences withstand the surging water.
Hundreds of military members, provincial staff and volunteers have been making sandbags and shoring up dikes since Selinger declared a state of emergency last week after heavy rainfall.
The river is expected to crest this afternoon in the Portage la Prairie area, and tomorrow downstream closer to Winnipeg.
Across the region, about 200 homes are considered vulnerable to the rising water.
Another 150 homes could be at risk if the province decides to cut a dike at the Hoop and Holler Bend to ease pressure on the river.
The premier has said that would be a last resort to prevent an uncontrolled breach downstream.