Officers from the Espanola detachment responded to the crash at 11:57 a.m. today. Highway 6 was closes between Clear Lake and the swing bridge at Little Current.
Two of the people involved in the collision were pronounced dead at the scene and three other occupants were taken to Health Sciences North in Sudbury.
The investigation is continuing with the assistance of an OPP collision reconstructionist and an OPP technical traffic collision investigator who are on scene at this time.
Highway 6 is still closed in both directions at Clear Lake Road south of Espanola to Manitoulin Island. It is anticipated that the highway is to be re-opened later in the evening.
Anyone who may have witnessed the collision is asked to call the OPP at 1-888-310-1122.